Summary of the work programme

The project focuses on long-term effects of deep brain stimulation in the subthalamic nucleus (STN-DBS) in a novel genetic animal model of Parkinson’s disease presenting with consecutive overexpression of α-synuclein. The effects of STN-DBS on structural, functional and behavioural alterations will be dissected and potential biomarkers for the development of feedback-controlled stimulation will be characterised. These findings will contribute to the pathophysiological understanding of mechanisms of action in deep brain stimulation and potential optimisation of therapeutic DBS also in the clinical setting.

Project leader

Prof. Dr. med. habil. Alexander Storch
E-Mail
Tel.: +49 381 494 9511

Dr. med. Mareike Fauser
E-Mail
Tel.: +49 381 494 9668

Institution

Rostock University Medical Center
Department of Neurology
Gehlsheimer Straße 20
18147 Rostock

Staff

Meike Statz 
Hanna Weber
Mehrnaz Sheibani (finished)
Francia Molina (finished)

Associated staff

Maria Kober
Dr. Renè Reese