C04 - Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson`s disease: Mechanisms of action, stimulation parameters and correlation with behaviour
Summary of the work programme
Parkinson's disease is characterised by typical motor symptoms and various non-motor symptoms such as depression and dementia, which are conceivably related to defective neuronal plasticity. Although deep brain stimulation is meanwhile a routine procedure in advanced Parkinson's disease, the mechanisms behind its effects on non-motor symptoms remain elusive. We here propose to investigate the mechanisms of deep-brain stimulation related to the interplay between cellular brain plasticity and non-motor symptoms in a rat model for Parkinson's disease. The results will contribute not only to the understanding of actions in deep-brain stimulation, but also to knowledge of the pathophysiological mechanisms underlying depression and cognitive dysfunction.
Manuel Ricken, Kathrin Badstübner, Jan Gimsa and Alexander Storch: DBS-induced cellular plasticity in the PD rat model. The many faces of Parkinson's disease - Motor and non-motor symptoms from prodromal to advanced disease stages, January 2018, Rostock, Germany.
Katrin Badstübner: Effekte der Tiefenhirnstimulation im 6-OHDA-Modell der Ratte, Research Workshop, University Medical Center, November 2017, Rostock, Germany.
Felix Bernsdorff (finished)
Charlotte Helf (finished)