C04 – Interactive effects of deep brain stimulation in the subthalamic nucleus on dopaminergic plasticity and neurogenesis in a genetic rat model of Parkinson’s disease: From non-motor impact to biomarker development
Summary of the work programme
The project focuses on long-term effects of deep brain stimulation in the subthalamic nucleus (STN-DBS) in a novel genetic animal model of Parkinson’s disease presenting with consecutive overexpression of α-synuclein. The effects of STN-DBS on structural, functional and behavioural alterations will be dissected and potential biomarkers for the development of feedback-controlled stimulation will be characterised. These findings will contribute to the pathophysiological understanding of mechanisms of action in deep brain stimulation and potential optimisation of therapeutic DBS also in the clinical setting.
Felix Bernsdorff (finished)
Charlotte Helf (finished)