C04 – Interactive effects of deep brain stimulation in the subthalamic nucleus on dopaminergic plasticity and neurogenesis in a genetic rat model of Parkinson’s disease: From non-motor impact to biomarker development

Summary of the work programme

The project focuses on long-term effects of deep brain stimulation in the subthalamic nucleus (STN-DBS) in a novel genetic animal model of Parkinson’s disease presenting with consecutive overexpression of α-synuclein. The effects of STN-DBS on structural, functional and behavioural alterations will be dissected and potential biomarkers for the development of feedback-controlled stimulation will be characterised. These findings will contribute to the pathophysiological understanding of mechanisms of action in deep brain stimulation and potential optimisation of therapeutic DBS also in the clinical setting.

Cooperation projects

A01 / A02 / A04 / B03 / C03

Project leader

Prof. Dr. med. habil. Alexander Storch
E-Mail
Tel.: +49 381 494 9511

Dr. med. Mareike Fauser
E-Mail
Tel.: +49 381 494 5276

Institution

Rostock University Medical Center
Department of Neurology
Gehlsheimer Straße 20
18147 Rostock

Staff

Francia Molina (finished)
Maria Kober

Associated staff

Dr. Renè Reese

Fellowship holders

Felix Bernsdorff (finished)
Charlotte Helf (finished)