Preject groups and projects

In order to achieve the main research objective to conceptualise energy autonomous, electrically active implants that are able to stimulate in a feedback-controlled manner, we divided the overall project into a project structure with three project areas. The three project areas A, B and C comprise an overall number of 14 research projects pursuing the following goals:

A Modelling and characterisation - in silico and in vitro
This project area aims at enhancing multi-scale modelling approaches and experimental characterisation of therapeutic electrical stimulation in tissue regeneration and neurology. For these purposes, we will pursue a more profound theoretical description of passive, dielectric tissue properties. We will also research on an adequate designing of electrical stimulation and its effects regarding cells, tissue and implant-tissue interactions.

B Functional materials, energy supply and reliability
Closely interrelated with in silico, in vitro and in vivo experiments, a conception of functional materials and energy supply is the main focus of project area B. To this end, research of bio-active, mechanically reliable materials and implant structures, miniaturised, energy-efficient electronics and energy harvesting systems for the independent energy supply of the electrically active implants is carried out.

C Regeneration of tissue structures and function - in vitro and in vivo
Project area C comprises clinically-translational-oriented research on innovative therapeutic approaches and principles for structural or functional tissue generation. In that, it aims at improving and extending the usage of electric stimulation or electrically active implants for the introduction of new therapy areas.

Furthermore the Collaborative Reserach Centre includes three service projects to support the overall project:                                                                                                     INF - Infrastructure Support Project, IRTG - Integrated Research Training Group and Z - Central Tasks of the Collaborative Research Centre

Project area A – Modelling and characterisation - in silico and in vitro
A01 Domain-specific languages for developing multi-scale, spatio-temporal, bio-chemical models and their application Modelling and SimulationProf. Dr. rer. nat. habil. Adelinde UhrmacherInstitute of Computer Science; Rostock
A02 Multi-scale models for studies on electrically active implants in due consideration of uncertainties in the input data Electromagnetic Field TheoryProf. Dr. rer. nat. habil. Ursula van RienenInstitute of General Electrical Engineering; Rostock
A03 Material surface charges and their influence on cell physiology and morphology Cell Biology, InterfacesProf. Dr. agr. habil. J. Barbara Nebe, Prof. Dr. rer. nat. habil. Sylvia SpellerCentre for Medical Research - Department of Cell Biology, Institute of Physics; Rostock
A04 Electrically conductive multilayer films for implant surfaces Soft Matter and Biophysics Prof. Dr. rer. nat. habil. Christiane A. HelmInstitute of Physics; Greifswald
A05 Dielectric characterisation of cells, tissues and materials BioelectricsProf. Dr. rer. nat. Jürgen F. KolbLeibniz Institute for Plasma Science and Technology; Greifswald
A06 Mathematical analysis of parameter dependent multi-scale models for electrically active implants Scientific ComputingProf. Dr. Jens StarkeInstitute of Mathematics; Rostock
Project area B - Functional materials, energy supply and reliability
B01 Electrically conductive and piezoactive materials for multifunctional implants for bone and cartilage regeneration Additive Manufacturing and Biomaterials Prof. Dr.-Ing. Hermann Seitz, Prof. Dr.-Ing. habil. Aldo R. BoccacciniInstitute of Microfluidics; Rostock, Institute of Biomaterials; Erlangen
B02 Transformation of mechanical energy as internal energy source for electrically active implants Biomechanics and Implant TechnologyPD Dr.-Ing. habil. Daniel KlüßDepartment of Orthopaedics; Rostock
B03 Energy-autonomous platform for electrical stimulation implants Computers in Technical Systems, Micro- and Nanotechnology of Electronic SystemsProf. Dr.-Ing. Dirk Timmermann, Prof. Dr.-Ing. Dennis HohlfeldInstitute for Applied Mecroelectronics and Computer Engineering, Institute for Electronic Appliances and Circuits; Rostock
B05 Assessment of the mechanical reliability of porous and functionally graded implant structures by local damage approach Structural MechanicsProf. Dr.-Ing. habil. Manuela SanderInstitute of Structural Mechanics; Rostock
Project area C - Regeneration of tissue structures - in vitro and in vivo
C01 Electrical stimulation of osseoinduction using alloplastic reconstruction plates after mandibular segmental resection Oral, Maxillofacial and Plastic SurgeryPD Dr. med. habil. Dr. dent. Peer W. KämmererPoliclinic of Oral-, Maxillofacial and Plastic Surgery; Rostock
C02 Electrical and mechanical stimulation of hyaline cartilage: Characterisation of biological response and stimulation parameters Biomechanics and Implant Technology, MicrofluidicsProf. Dr. med. habil. Dipl.-Ing. Rainer Bader, Prof. Dr.-Ing. Hermann SeitzDepartment of Orthopaedics, Institute of Microfluidics; Rostock
C03 Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms Physiology, PharmacologyProf. Dr. med. habil. Rüdiger Köhling, Prof. Dr. med. vet. habil. Angelika RichterOscar-Langendorff-Institute of Physiology; Rostock, Institute for Pharmacology, Pharmacy and Toxicology; Leipzig
C04 Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson`s disease: Mechanisms of action, stimulation parameters and correlation with behavior NeurologyProf. Dr. med. habil. Alexander StorchDepartment of Neurology; Rostock
Service Projects
INF Infrastructure Support Project Prof. Dr.-Ing. Sascha Spors, Prof. Dr. rer. nat. habil. Ursula van Rienen, Prof. Dr.-Ing. habil. Manuela SanderInstitute of Communications Engineering, Institute of General Electrical Engineering, Institute of Structural Mechanics; Rostock
IRTG Integrated Research Training Group Prof. Dr. med. habil. Alexander Storch, Prof. Dr.-Ing. Sascha SporsDepartment of Neurology, Institute of Communications Engineering; Rostock
Z Central Tasks of the Collaborative Research Centre Prof. Dr. rer. nat. habil. Ursula van RienenInstitute of General Electrical Engineering; Rostock

Participating Institutions

Logo Friedrich-Alexander-Universität Erlangen-Nürnberg
Logo Ernst August Arndt Universität
[Translate to English:] Logo INP