C02 – Electrical and mechanical stimulation of hyaline cartilage: Characterisation of biological response and different stimulation parameters

Summary of the work programme

One project goal is to develop a stimulation device for targeted electrical stimulation of articular cartilage for future human application. To this end, a demonstrator of a multi-electrode array implant is developed, including a feedback system for determining the electrical conductivity and dielectric properties of the surrounding tissue, using a human ex vivo model of the knee joint. Furthermore, the rheological, tribological, and biological properties of biphasic scaffold structures to repair osteochondral defects are investigated. Therefore, further studies on gender-specific molecular patterns of chondrogenic and osteogenic cell differentiation are conducted.

Cooperation projects

A01 / A01 / A03 / A04 / A05 / B01 / B02 / B03 / C01 / C03 / S01 / INF

Institutions

Rostock University Medical Center
Department of Orthopaedics
Doberaner Straße 142
18057 Rostock

University of Rostock
Chair of Mikrofluidics
Justus-von-Liebig Weg 6
18059 Rostock

Staff

Vivica Freiin Grote
E-Mail

Carla Maximiliane Niendorf
E-Mail

Associated staff

Dr. med. Sina Gräber
Mario Jackszis
Prof. Dr. med. Christoph Lutter
Iman Soodmand 
Alexander Riess
Dr. rer. hum. Janine Waletzko-Hellwig

Former staff

Nada Abroug
Pedram Azizi
Dr. rer. hum. Simone Krüger
Dr.-Ing. Roland Matzmohr
Dr. rer. hum. Franziska Sahm
Zezhong Song
Mareike Specht
Dr. med. Martin Stephan
Dr. rer. nat. Marco Stubbe
Prof. Dr. Thomas Tischer
Dr.-Ing. Alina Weizel