Summary of the Research Programme of CRC Electrically Active Implants – ELAINE

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European populations are ageing rapidly. By the year 2060, every third person living in Germany will be older than 65. For this reason, the social and socio-economic relevance of regenerative therapies is clearly increasing. This holds particularly true for implants: the older the population grows, the more medical implants for various indication areas are required and the more often they have to be replaced during the course of therapy.

The research vision pursued by the CRC 1270 ELAINE (ELectrically Active ImplaNts) focuses on novel electrically active implants. Specifically, ELAINE addresses implants employed for the regeneration of bone and cartilage, and implants for deep brain stimulation to treat movement disorders.

Three central research objectives are a means to implement the research vision. The first objective is to establish innovative energy autonomous implants that allow a feedback-controlled electrical stimulation. A second objective is efficient systematic multi-scale studies to enable rapid progress in targeted implant improvements and patient-specific therapies. The third long-term objective is to analyse the basic mechanisms of electrical stimulation in bone, cartilage and brain, and to translate this knowledge in clinical practice.


  • July 2018: Frank Krüger from the INF project has received a GESIS grant for a research stay to work on the topic of automatic extraction references to research artefacts from scientific publications.

  • Diana Lu of Columbia University, US, has been granted a RISE DAAD stipend für an internship in the group of Prof. Ursula van Rienen
  • News release on durability of joint replacement implants, see also Focus-Online
  • TV-Report from NDR about CRC ELAINE
  • On 7th december 2017, Julius Zimmermann was honored as one of the best Master graduates of the Faculty of Mathematics and Natural Sciences of the University of Rostock. Prospectively, he will research under the supervision of Prof. Ursula van Rienen in the project A02 as part of ELAINE in the field of multi-scale model.                                                                                        News archiv


  • D. Truong C. R. Bahls B. Nebe U. van Rienen: Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio‐chemo‐mechanical model. Int J Numer Meth Biomed Engng. 2018;34:e3097., also highlighted as Cover image
  • Y. Bansod, T. Matsumoto, K. Nagayama, J. Bursa: A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell. ASME. J Biomech Eng. 2018; doi:10.1115/1.4040246.
  • S. Staehlke, H. Rebl, B. Finke, P. Mueller, M. Gruening, B. Nebe: Enhanced calcium ion mobilization in osteoblasts on amino group containing plasma polymer nanolayer, Cell & Biosciences 8 (2018) 22 (pp. 11), open access,
  • D. Kluess, H.-E. Lange, H. Heyer, M. Sander, W. Mittelmeier, R. Bader: Supplementary finite element analysis in experimental testing of total hip stems, Materials Testing, April 2018, Jg. 60, Ausgabe 5. Seiten: 489–494,
  • K.K. Sriperumbudur, H.W. Pau, U. van Rienen, Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study, IEEE Trans.on Biomedical Engineering, Vol.65, Issue 3, 658-668, also highlighted as Feature Story, March 2018 (funded by RTG 1505 Welisa)

Further participating Institutions:

Logo Universitätsmedizin Rostock
Logo Friedrich-Alexander-Universität Erlangen-Nürnberg
Logo Ernst August Arndt Universität
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Logo Universität Leipzig