C01 - Electrical stimulation of osseoinduction using alloplastic reconstruction plates after mandibular segmental resection

Summary of the work programme

This project is focused on regeneration of larger defects of the bony mandible via electric stimulation. Based on previous research in the literature and from our group on electrically active implants, we hypothesise that bioactivation of mandibular reconstruction plate systems via electrical stimulation is a possibility to regenerate the lack of surrounding bone without the need for secondary bone transplantation. Accordingly, electrically active components of a reconstruction system will be tested in vitro using osteogenic stem cells. Afterwards, an implantable device for endogenous stimulation of osseous regeneration will be used in combination with a mandibular reconstruction plate system together with the respective osteogenic stem cells in order to bridge a critical-size defect in mini-pigs. To the best of our knowledge, this is the first study aiming for in vitro and in vivo evaluation of an electrical stimulation system for regeneration of larger osseous defects.

Cooperation projects

A02 / B02 / B03 / B05 / C02

Publications

Hendrikje Raben, Peer W. Kämmerer, Rainer Bader and Ursula van Rienen: Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect. Applied Sciences, volume 9(10), May 2019. ISSN 2076-3417. doi.org/10.3390/app9102160

Josefine Ziebart, Siyuan Fan, Christian Schulze, Peer W. Kämmerer, Rainer Bader and Anika Jonitz-Heincke: Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. Bone & Joint Research, volume 7 (2): pages 187-195, February 2018. doi.org/10.1302/2046-3758.72.bjr-2017-0228.r1

Ursula van Rienen, Ulf Zimmermann, Hendrikje Raben and Peer W.Kämmerer: Preliminary Numerical Study on Electrical Stimulation at Alloplastic Reconstruction Plates of the Mandible. In Scientific Computing in Electrical Engineering, pages 3-11. Springer International Publishing, April 2018. doi.org/10.1007/978-3-319-75538-0_1

Martin Heller, Vinay V. Kumar, Andreas Pabst, Jürgen Brieger, Bilal Al-Nawas and Peer W. Kämmerer: Osseous response on linear and cyclic RGD-peptides immobilized on titanium surfaces in vitro and in vivo. Journal of Biomedical Materials Research Part A, volume 106 (2): pages 419-427, October 2017. doi.org/10.1002/jbm.a.36255

Peer W. Kämmerer, Malte Scholz, Maria Baudisch, Jan Liese, Katharina Wegner, Bernhard Frerich and Hermann Lang: Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects. In Vivo Stem Cells International, volume 2017: pages 1-9, August 2017. doi.org/10.1155/2017/3548435

Hendrikje Raben, Christian Schmidt, Karthik Sridhar, Peer W. Kämmerer and Ursula van Rienen: Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible. Current Directions in Biomedical Engineering, volume 3 (2): January 2017. doi.org/10.1515/cdbme-2017-0128