C01 - Electrical stimulation of osseoinduction using alloplastic reconstruction plates after mandibular segmental resection

Summary of the work programme

This project is focused on regeneration of larger defects of the bony mandible via electric stimulation. Based on previous research in the literature and from our group on electrically active implants, we hypothesise that bioactivation of mandibular reconstruction plate systems via electrical stimulation is a possibility to regenerate the lack of surrounding bone without the need for secondary bone transplantation. Accordingly, electrically active components of a reconstruction system will be tested in vitro using osteogenic stem cells. Afterwards, an implantable device for endogenous stimulation of osseous regeneration will be used in combination with a mandibular reconstruction plate system together with the respective osteogenic stem cells in order to bridge a critical-size defect in mini-pigs. To the best of our knowledge, this is the first study aiming for in vitro and in vivo evaluation of an electrical stimulation system for regeneration of larger osseous defects.

Cooperation projects

A02 / B02 / B03 / B05 / C02