C01 - Electrical stimulation of osseoinduction using alloplastic reconstruction plates after mandibular segmental resection

Summary of the work programme

This project is focused on regeneration of larger defects of the bony mandible via electric stimulation. Based on previous research in the literature and from our group on electrically active implants, we hypothesise that bioactivation of mandibular reconstruction plate systems via electrical stimulation is a possibility to regenerate the lack of surrounding bone without the need for secondary bone transplantation. Accordingly, electrically active components of a reconstruction system will be tested in vitro using osteogenic stem cells. Afterwards, an implantable device for endogenous stimulation of osseous regeneration will be used in combination with a mandibular reconstruction plate system together with the respective osteogenic stem cells in order to bridge a critical-size defect in mini-pigs. To the best of our knowledge, this is the first study aiming for in vitro and in vivo evaluation of an electrical stimulation system for regeneration of larger osseous defects.

Cooperation projects

A02 / B02 / B03 / B05 / C02

Publications

2019

Raben, Hendrikje; Kämmerer, Peer W.; Bader, Rainer; van Rienen, Ursula (2019): Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect. In: Applied Sciences 9 (10), S. 2160. DOI: 10.3390/app9102160.
 

2018

van Rienen, Ursula; Zimmermann, Ulf; Raben, Hendrikje; Kämmerer, Peer W. (2018): Preliminary Numerical Study on Electrical Stimulation at Alloplastic Reconstruction Plates of the Mandible. In: Scientific Computing in Electrical Engineering 28, S. 3–11. DOI: 10.1007/978-3-319-75538-0_1.

Ziebart, Josefin; Fan, Siyuan; Schulze, Christian; Kämmerer, Peer W.; Bader, Rainer; Jonitz‑Heincke, Anika (2018): Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. In: Bone & Joint Research 7 (2), S. 187–195. DOI: 10.1302/2046-3758.72.bjr-2017-0228.r1.


2017

Heller, Martin; Kumar, Vinay V.; Pabst, Andreas; Brieger, Jürgen; Al-Nawas, Bilal; Kämmerer, Peer W. (2017): Osseous response on linear and cyclic RGD-peptides immobilized on titanium surfaces in vitro and in vivo. In: Journal of Biomedical Materials Research Part A 106 (2), S. 419–427. DOI: 10.1002/jbm.a.36255.

Kämmerer, Peer W.; Scholz, Malte; Baudisch, Maria; Liese, Jan; Wegner, Katharina; Frerich, Bernhard; Lang, Hermann (2017): Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo. In: Stem Cells International, S. 1–9. DOI: 10.1155/2017/3548435.

Raben, Hendrikje; Schmidt, Christian; Sridhar, Karthik; Kämmerer, Peer W.; van Rienen, Ursula (2017): Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible. In: Current Directions in Biomedical Engineering 3 (2). DOI: 10.1515/cdbme-2017-0128.

Conference papers

2020

Plocksties, Franz; Niemann, Christoph; Bader, Rainer; Möws, Fabian; Seitz, Hermann; Kämmerer, Peer W. et al. (2020): Requirements and Design of an Implant for Electrical Stimulation for Bone Regeneration in Animals. IEEE Conference on Life Sciences and Technologies (LifeTech). Kyoto, Japan, March 2020.