A02 - Multi-scale models for studies on electrically active implants in due consideration of uncertainties in the input data

Summary of the work programme

For therapies employing electrically active implants, numerical models are central in determining the resulting electric field distribution in the targeted tissue. Only multi-scale models that also include interacting bioelectrical, biochemical, biomechanical and thermal effects meet the specific character of biological tissue. We will investigate and advance appropriate finite element-based micro- and macroscopic models for bone, cartilage and deep brain as well as scale-bridging techniques and, furthermore, methods for uncertainty quantification as the dielectric tissue properties exhibit large variations. The simulation models will contribute to derive best-possible and robust inter-individual stimulation parameters, and, in turn, a safer therapy planning.

Cooperation projects

A01 / A06 / B01 / B02 / B03 / B05 / C01 / C02 / C03 / C04

Publications

Abdul R. Farooqi, Julius Zimmermann, Rainer Bader, Ursula van Rienen: Numerical Simulation of Electroactive Hydrogels for Cartilage–Tissue Engineering. Materials 2019, 12(18), 2913, September 2019. doi.org/10.3390/ma12182913

Hendrikje Raben, Peer W. Kämmerer, Rainer Bader and Ursula van Rienen: Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect. Applied Sciences, volume 9(10), May 2019. ISSN 2076-3417. doi.org/10.3390/app9102160

Abdul Razzaq Farooqi, Rainer Bader and Ursula van Rienen: Numerical study on electromechanics in cartilage tissue with respect to its electrical properties. Tissue Engineering Part B: Reviews, April 2019. doi.org/10.1089/ten.teb.2018.0214

Duy Truong, Christian R. Bahls, Barbara Nebe and Ursula van Rienen: Cover Image. International Journal for Numerical Methods in Biomedical Engineering, volume 34 (8): page e3135, August 2018. ISSN 2040-7947. doi.org/10.1002/(ISSN)2040-7947

Duy Truong, Christian Rüdiger Bahls, and Ursula van Rienen: An efficient 2D implementation of a bio-chemo-mechanical modelemploying a quadratic representation to study cells on micro-postarrays, Finite Elements in Analysis and Design, volume 146:pages 16-27, May 2018. dx.doi.org/10.1016/j.finel.2018.04.004

Duy Truong, Christian R. Bahls, Barbara Nebe and Ursula van Rienen: Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model. International Journal for Numerical Methods in Biomedical Engineering, page e3097, May 2018. doi.org/10.1002/cnm.3097

Josefin Ziebart, Tina Sellmann, Karin Porath, Bachir Delenda, Ursula van Rienen, Rainer Bader and Rüdiger Köhling: Investigation of calcium channels involved in directed migration of human osteoblast in a direct current field. Orthopaedic Proceedings, volume SUPP_4: pages 4-4, April 2018. online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.2018.4.004

Ursula van Rienen, Ulf Zimmermann, Hendrikje Raben, and Peer W.Kämmerer: Preliminary Numerical Study on Electrical Stimulation at Alloplastic Reconstruction Plates of the Mandible. In Scientific Computing in Electrical Engineering, pages 3-11. Springer International Publishing, April 2018. doi.org/10.1007/978-3-319-75538-0_1

Yogesh Bansod, Takeo Matsumoto, Kazuaki Nagayama and Jiri Bursa: A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell. The American Society of Mechanical Engineers. Journal of Biomechanical Engineering, volume 140 (10), April 2018. doi:10.1115/1.4040246

Kiran Kumar Sriperumbudur, Hans Wilhelm Pau and Ursula van Rienen: Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study, IEEE Transactions on Biomedical Engineering, volume 65(3):pages 658-668, March 2018. dx.doi.org/10.1109/tbme.2017.2700361

Josefine Ziebart, Siyuan Fan, Christian Schulze, Peer W. Kämmerer, Rainer Bader and Anika Jonitz-Heincke: Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. Bone & Joint Research, volume 7 (2): pages 187-195, February 2018. doi.org/10.1302/2046-3758.72.bjr-2017-0228.r1

Christian Schmidt, Eleanor Dunn, Madeleine Lowery, and Ursula van Rienen: Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model. IEEE Transactions on Neural Systems and Rehabilitation Engineering, volume 26 (2): pages 281-290, February 2018. doi.org/10.1109/tnsre.2016.2608925

Christian R. Bahls, Duy Truong and Ursula van Rienen: Semi-analytical representation of the activation level in stress  fibre directions as alternative to the angular representation in the bio-chemo-mechanical model for cell contractility. Journal of the Mechanical Behavior of Biomedical Materials, volume 77: pages 527-533, January 2018. doi.org/10.1016/j.jmbbm.2017.10.011

Christian Schmidt and Ursula van Rienen: Adaptive Estimation of the Neural Activation Extent in Computational Volume Conductor Models of Deep Brain Stimulation. IEEE Transactions on Biomedical Engineering, pages 11, December 2017. doi.org/10.1109/tbme.2017.2758324

Robert Bestel, Revathi Appali, Ursula van Rienen and Christiane Thielemann: Effect of Morphologic Features of Neurons on the Extracellular Electric Potential. A Simulation Study Using Cable Theory and Electro-Quasi-Static Equations. Neural Computation, volume 29 (11): pages 2955-2978, November 2017. doi.org/10.1162/neco_a_01019

Hendrikje Raben, Christian Schmidt, Karthik Sridhar, Peer W. Kämmerer and Ursula van Rienen: Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible. Current Directions in Biomedical Engineering, volume 3 (2): January 2017. doi.org/10.1515/cdbme-2017-0128

Conference papers

Susanne Staehlke, Martina Grüning, Julius Zimmermann, Thomas Freitag, Alexander Prokopp, Ingo Barke, Sylvia Speller, Ursula van Rienen, Barbara Nebe: Osteoblast behavior upon electrical stimulation in vitro. book of abstracts pp. 1708-09. PS2-12-43930th,  Annual Conference of the European Society for Biomaterials, September 2019, Dresden, Germany.

Alina Weizel, Julius Zimmermann, Alexander Riess, Simone Krüger, Rainer Bader, Ursula van Rienen, Hermann Seitz: Numerical Numerical simulation of the electric field distribution in an electrical stimulation device for scaffolds settled with cartilaginous cells. EMBC, July 2019, Berlin, Germany. doi:10.1109/EMBC.2019.8857760

Yogesh Deepak Bansod and Ursula van Rienen: Numerical analysis of electromechanically driven bone remodeling using the open-source software framework. In: 41st International Engineering in Medicine and Biology Conference (EMBC), July 2019, Berlin, Germany.

Max Schröder, Hendrikje Raben, Frank Krüger, Andreas Ruscheinski, Ursula van Rienen, Adelinde Uhrmacher, Sascha Spors: PROVenance Patterns in Numerical Modelling and Finite Element Simulation Processes of Bio-electric Systems. 41st International Engineering in Medicine and Biology Conference (EMBC), July 2019, Berlin, Germany.

Kai Budde, Julius Zimmermann, Elisa Neuhaus, Max Schröder, Adelinde M. Uhrmacher and Ursula van Rienen: Requirements for Documenting Electrical Cell Stimulation Experiments for Replicability and Numerical Modeling. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 2019, Berlin, Germany.

Revathi Appali, Kiran K. Sriperumbudur, Ursula van Rienen: Extracellular Stimulation of Neural Tissues: Activating Function and Sub-threshold Potential Perspective. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 2019, Berlin, Germany.

Max Schröder, Frank Krüger, Robert Zepf, Ursula van Rienen, Sascha Spors: A Comprehensive Approach to Support Research Processes in the CRC 1270 ELAINE. WissKom2019, June 2019, Jülich, Germany.

Talks

Konstantin Butenko: Open-Source Simulation Platform for Deep Brain Stimulation. The 12th International Conference on Scientific Computing in Electrical Engineering (SCEE), September 2018, Taormina, Italy.

Julius Zimmermann: Electromagnetic stimulation chambers for cartilage regeneration. The 12th International Conference on Scientific Computing in Electrical Engineering (SCEE), September 2018, Taormina, Italy.

Yogesh Deepak Bansod, Ursula van Rienen, Jiri Bursa: A finite element bendo-tensegrity model of eukaryotic cell. The 10th European Solid Mechanics Conference (ESMC), July 2018, Bologna, Italy.

Yogesh Deepak Bansod, Ursula van Rienen: Numerical analysis of electromechanically driven bone remodeling using the open-source software framework. The 41st International Engineering in Medicine and Biology Conference (EMBC), July 2019, Berlin, Germany. 

Revathi Appali, Kiran K. Sriperumbudur, Ursula van Rienen: Extracellular Stimulation of Neural Tissues: Activating Function and Sub-threshold Potential Perspective. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 2019, Berlin, Germany.

Ursula van Rienen: Collaborative Research Centre 1270 ELAINE, acatech Themennetzwerk Gesundheitstechnologie, February 2018, Frankfurt am Main, Germany.

Ursula van Rienen: Computational Studies on the Volume of Activated Tissue in Deep Brain Stimulation. Max Planck Institute for Human Cognitive and Brain Sciences. Invited Talk, February 2018, Leipzig, Germany.

Ursula van Rienen: SFB 1270 ELAINE - ELektrisch Aktive ImplaNtatE, Research Workshop University Medical Center, November 2017, Rostock, Germany.

Posters

Julius Zimmermann and Ursula van Rienen: Electromagnetic Stimulation Chambers for Chondrocytes. Virtual Physiological Human conference (VPH) 2018, September 2018, Zaragoza, Spain.

Yogesh Deepak Bansod, Märuan Kebbach, Rainer Bader, and Ursula van Rienen: A Piezoelectric Strain-Adaptive Bone Remodeling Simulation. 41st International  Engineering in Medicine and Biology Conference (EMBC), July 2019, Berlin, Germany.

Julius Zimmermann and Ursula van Rienen: Automated modeling of electro-magnetic stimulation experiments - FEniCS for reproducible and reliable modeling of realistic geometries. Fenics '19, June 2019, Washington, USA.

Christian Bahls, Duy Truong, Barbara Nebe and Ursula van Rienen: Modelling contraction of biological cells under electric field exposure using a bio-chemo-mechanical model, 11th International Symposium on Electric and Magnetic Fields, April 2018, Darmstadt, Germany

Project leader

Prof. Dr. rer. nat. habil. Ursula van Rienen
E-Mail
Tel.: +49 381 498 7070

Institution

University of Rostock
Institute of General Electrical Engineering
Albert-Einstein-Str. 2
18059 Rostock

Junior Research Group Leader

Dr. Revathi Appali

Fellowship holders

Sushain Magotra (finished)