A02 - Multi-scale models for studies on electrically active implants in due consideration of uncertainties in the input data

Summary of the work programme

For therapies employing electrically active implants, numerical models are central in determining the resulting electric field distribution in the targeted tissue. Only multi-scale models that also include interacting bioelectrical, biochemical, biomechanical and thermal effects meet the specific character of biological tissue. We will investigate and advance appropriate finite element-based micro- and macroscopic models for bone, cartilage and deep brain as well as scale-bridging techniques and, furthermore, methods for uncertainty quantification as the dielectric tissue properties exhibit large variations. The simulation models will contribute to derive best-possible and robust inter-individual stimulation parameters, and, in turn, a safer therapy planning.

Cooperation projects

A01 / A06 / B01 / B02 / B03 / B05 / C01 / C02 / C03 / C04

Publications

2020

Butenko, Konstantin; Bahls, Christian R.; Schröder, Max; Köhling, Rüdiger; van Rienen, Ursula (2020): OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling. In: PLoS computational biology 16 (7), e1008023. DOI: 10.1371/journal.pcbi.1008023 .
 

2019

Farooqi, Abdul Razzaq; Bader, Rainer; van Rienen, Ursula (2019): Numerical Study on Electromechanics in Cartilage Tissue with Respect to Its Electrical Properties. In: Tissue engineering. Part B, Reviews 25 (2), S. 152–166. DOI: 10.1089/ten.teb.2018.0214.

Farooqi, Abdul Razzaq; Zimmermann, Julius; Bader, Rainer; van Rienen, Ursula (2019): Numerical Simulation of Electroactive Hydrogels for Cartilage-Tissue Engineering. In: Materials 12 (18). DOI: 10.3390/ma12182913.

Krüger, Simone; Achilles, Sophie; Zimmermann, Julius; Tischer, Thomas; Bader, Rainer; Jonitz‑Heincke, Anika (2019): Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields. In: Journal of clinical medicine 8 (11). DOI: 10.3390/jcm8111771.

Raben, Hendrikje; Kämmerer, Peer W.; Bader, Rainer; van Rienen, Ursula (2019): Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect. In: Applied Sciences 9 (10), S. 2160. DOI: 10.3390/app9102160.

Rohde, Marco; Ziebart, Josefin; Kirschstein, Timo; Sellmann, Tina; Porath, Katrin; Kühl, Friederike; Delenda, Bachir; Bahls, Christian; van Rienen, Ursula; Bader, Rainer; Köhling, Rüdiger (2019): Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels. In: Frontiers in bioengineering and biotechnology 7, S. 422. DOI: 10.3389/fbioe.2019.00422.

2018

Bahls, Christian R.; Truong, Duy; van Rienen, Ursula (2018): Semi-analytical representation of the activation level in stress fibre directions as alternative to the angular representation in the bio-chemo-mechanical model for cell contractility. In: Journal of the Mechanical Behavior of Biomedical Materials 77, S. 527–533. DOI: 10.1016/j.jmbbm.2017.10.011.

Bansod, Yogesh Deepak; Matsumoto, Takeo; Nagayama, Kazuaki; Bursa, Jiri (2018): A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell. In: Journal of Biomechanical Engineering 140 (10), S. 101001. DOI: 10.1115/1.4040246.

Schmidt, Christian; Dunn, Eleanor; Lowery, Madeleine; van Rienen, Ursula (2018): Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model. In: Transactions on Neural Systems and Rehabilitation Engineering 26 (2), S. 281–290. DOI: 10.1109/tnsre.2016.2608925.

Sriperumbudur, Kiran Kumar; Pau, Hans Wilhelm; van Rienen, Ursula (2018): Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study. In: Transactions on Biomedical Engineering 65 (3), S. 658–668. DOI: 10.1109/tbme.2017.2700361.

Truong, Duy; Bahls, Christian R.; Nebe, Barbara J.; van Rienen, Ursula (2018): Cover Image. In: International Journal for Numerical Methods in Biomedical Engineering 34 (8), e3135. DOI: 10.1002/(ISSN)2040-7947.

Truong, Duy; Bahls, Christian R.; Nebe, Barbara J.; van Rienen, Ursula (2018): Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model. In: International Journal for Numerical Methods in Biomedical Engineering, e3097. DOI: 10.1002/cnm.3097.

Truong, Duy; Bahls, Christian R.; van Rienen, Ursula (2018): An efficient 2D implementation of a bio-chemo-mechanical model employing a quadratic representation to study cells on micro-post arrays. In: Finite Elements in Analysis and Design 146, S. 16–27. DOI: 10.1016/j.finel.2018.04.004.

van Rienen, Ursula; Zimmermann, Ulf; Raben, Hendrikje; Kämmerer, Peer W. (2018): Preliminary Numerical Study on Electrical Stimulation at Alloplastic Reconstruction Plates of the Mandible. In: Scientific Computing in Electrical Engineering 28, S. 3–11. DOI: 10.1007/978-3-319-75538-0_1.
 

2017

Bestel, Robert; Appali, Revathi; van Rienen, Ursula; Thielemann, Christiane (2017): Effect of Morphologic Features of Neurons on the Extracellular Electric Potential: A Simulation Study Using Cable Theory and Electro-Quasi-Static Equations. In: Neural Computation 29 (11), S. 2955–2978. DOI: 10.1162/neco_a_01019.

Raben, Hendrikje; Schmidt, Christian; Sridhar, Karthik; Kämmerer, Peer W.; van Rienen, Ursula (2017): Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible. In: Current Directions in Biomedical Engineering 3 (2). DOI: 10.1515/cdbme-2017-0128.

Schmidt, Christian; van Rienen, Ursula (2017): Adaptive Estimation of the Neural Activation Extent in Computational Volume Conductor Models of Deep Brain Stimulation. In: Transactions on Biomedical Engineering 65 (8), S. 1. DOI: 10.1109/tbme.2017.2758324.

Conference papers

2019

Appali, Revathi; Sriperumbudur, Kiran Kumar; van Rienen, Ursula (2019): Extracellular Stimulation of Neural Tissues: Activating Function and Sub-threshold Potential Perspective. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

Bansod, Yogesh Deepak; van Rienen, Ursula (2019): Numerical analysis of electromechanically driven bone remodeling using the open-source software framework. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

Budde, Kai; Zimmermann, Julius; Neuhaus, Elisa; Schröder, Max; Uhrmacher, Adelinde M.; van Rienen, Ursula (2019): Requirements for Documenting Electrical Cell Stimulation Experiments for Replicability and Numerical Modeling. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

Butenko, Konstantin; Bahls, Christian; van Rienen, Ursula (Hg.) (2019): Evaluation of Epistemic Uncertainties for Bipolar Deep Brain Stimulation in Rodent Models. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019. Online verfügbar unter https://ieeexplore.ieee.org/abstract/document/8857910.

Schröder, Max; Krüger, Frank; Zepf, Robert; van Rienen, Ursula; Spors, Sascha (2019): A Comprehensive Approach to Support Research Processes in the CRC 1270 ELAINE. 8. Konferenz WissKom der Zentralbibliothek des Forschungszentrums Jülich. Jülich, Germany, June 2019.

Schröder, Max; Raben, Hendrikje; Krüger, Frank; Ruscheinski, Andreas; van Rienen, Ursula; Uhrmacher, Adelinde M.; Spors, Sascha (2019): PROVenance Patterns in Numerical Modelling and Finite Element Simulation Processes of Bio-electric Systems. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019. DOI: 10.1109/EMBC.2019.8856841.

Stählke, Susanne; Grüning, Martina; Zimmermann, Julius; Freitag, Thomas; Prokopp, Alexander; Barke, Ingo et al. (2019): Osteoblast behavior upon electrical stimulation in vitro. Annual Conference of the European Society for Biomaterials. Dresden, Germany, September 2019.

Weizel, Alina; Zimmermann, Julius; Riess, Alexander; Krüger, Simone; Bader, Rainer; van Rienen, Ursula; Seitz, Hermann (2019): Numerical simulation of the electric field distribution in an electrical stimulation device for scaffolds settled with cartilaginous cells. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019. doi:10.1109/EMBC.2019.8857760

Wilsdorf, Pia; Zimmermann, Julius; Dombrowsky, Marcus; van Rienen, Ursula; Uhrmacher, Adelinde M. (2019): Simulation Experiment Schemas – Beyond Tools and Simulation Approaches. Winter Simulation Conference. National Harbor, United States of America, December 2019.

Talks

2019

Appali, Revathi; Sriperumbudur, Kiran Kumar; van Rienen, Ursula (2019): Extracellular Stimulation of Neural Tissues: Activating Function and Sub-threshold Potential Perspective. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

Bansod, Yogesh Deepak; van Rienen, Ursula (2019): Numerical analysis of electromechanically driven bone remodeling using the open-source software framework. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

van Rienen, Ursula (2019): Zu erwartende Unsicherheit in der Simulation. Themennachmittag “Zukunft des Alterns” im Rahmen der Ausstellung „Experiment Zukunft“. Kunsthalle Rostock. Rostock, Germany, March 2019.

van Rienen, Ursula (2019): Chancen und Herausforderungen elektrisch aktiver Implantate. Themenabend: “Hybride Zukunft – Hybrider Mensch”. Kunsthalle Rostock. Rostock, Germany, April 2019.

van Rienen, Ursula (2019): ELAINE - ELectrically Active ImplaNts, Einleitung zur zur öffentlichen Informationsveranstaltung „Aktive Implantate in der Medizin – welche Therapiemöglichkeiten bietet die Zukunft. Rostock, Germany, April 2019.

van Rienen, Ursula (2019): ELAINE - ELectrically Active ImplaNts. Gemeinsamer Workshop des SFB 1261 und des SFB 1270. University of Rostock. Rostock, Germany, May 2019.

van Rienen, Ursula (2019): Länger leben, aber wie? – Forschung für ein längeres und gesünderes Leben: Möglichkeiten und gesellschaftliche Implikationen. Internationales Symposium der Universität Rostock “Keine Zukunft ohne interdisziplinäre Forschung“,. University of Rostock. Rostock, Germany, November 2019.

van Rienen, Ursula (2019): Novel electrically active implants – reliability and challenges. Deutscher Verbande für Materialforschung und –prüfung, Arbeitskreis „Zuverlässigkeit von Implantaten und Biostrukturen“. Rostock, Germany, November 2019.

van Rienen, Ursula (2019): Simulation elektromagnetischer Felder – mein Weg aus der Mathematik bis hin zu elektrisch aktiven Implantaten. University of Rostock. Rostock, Germany, December 2019.

Zimmermann, Julius (2019): Parameter estimation and uncertainty quantification for electrically active implants. Uni Heidelberg, Xi'an University of Technology und Heidelberg Institute for Theoretical Studies. Heidelberg, Germany, December 2019.
 

2018

Bansod, Yogesh Deepak; van Rienen, Ursula; Bursa, Jiri (2018): A finite element bendo-tensegrity model of eukaryotic cell. The 10th European Solid Mechanics Conference. Bologna, Italy, July 2018.

Butenko, Konstantin (2018): Open-Source Simulation Platform for Deep Brain Stimulation. The 12th International Conference on Scientific Computing in Electrical Engineering. Taormina, Italy, September 2018.

van Rienen, Ursula (2018): Collaborative Research Centre 1270 ELAINE. acatech Themennetzwerk Gesundheitstechnologie. Frankfurt am Main, Germany, February 2018.

van Rienen, Ursula (2018): Computational Studies on the Volume of Activated Tissue in Deep Brain Stimulation. Max Planck Institute for Human Cognitive and Brain Sciences. Leipzig, Germany, February 2018.

Zimmermann, Julius (2018): Electromagnetic stimulation chambers for cartilage regeneration. 12th International Conference on Scientific computing in Electrical Engineering (SCEE). Taormina, Italy, September 2018.
 

2017

van Rienen, Ursula (2017): SFB 1270 ELAINE - ELektrisch Aktive ImplaNtatE. Research Workshop University Medical Center. Rostock, Germany, November 2017.

Posters

2019

Bansod, Yogesh Deepak; Kebbach, Märuan; Bader, Rainer; van Rienen, Ursula (2019): A Piezoelectric Strain-Adaptive Bone Remodeling Simulation. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany.

Farooqi, Abdul Razzaq; Zimmermann, Julius; Bader, Rainer; van Rienen, Ursula (2019): Numerical Simulation of Electro-Active Hydrogels to Be Used for Cartilage Tissue Engineering. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany.

Sriperumbudur, Kiran Kumar; Sridhar, Karthik; van Rienen, Ursula; Appali, Revathi (2019): Evaluation of heat distribution during deep brain stimulation. Forschungscamp 2019. University of Rostock. Rostock, Germany.

Stählke, Susanne, Grüning Martina Zimmermann, Julius Freitag, Thomas Prokopp, Alexander Barke, Ingo Speller, Sylvia van Rienen, Ursula Nebe, Barbara J. (2019): Osteoblast behavior upon electrical stimulation in vitro. University of Rostock. Rostock, Germany.

Zimmermann, Julius; van Rienen, Ursula (2019): Automated modeling of electro-magnetic stimulation experiments - FEniCS for reproducible and reliable modeling of realistic geometries. FEniCS Project. Washington, United States of America.
 

2018

Bahls, Christian R.; Truong, Duy; Nebe, Barbara J.; van Rienen, Ursula (2018): Modelling contraction of biological cells under electric field exposure using a bio-chemo-mechanical model. 11th International Symposium on Electric and Magnetic Fields. Darmstadt, Germany.

Zimmermann, Julius; van Rienen, Ursula (2018): Electromagnetic Stimulation Chambers for Chondrocytes. Virtual Physiological Human conference. Zaragoza, Spain.

Project leader

Prof. Dr. rer. nat. habil. Ursula van Rienen
E-Mail
Tel.: +49 381 498 7070

Institution

University of Rostock
Institute of General Electrical Engineering
Albert-Einstein-Str. 2
18059 Rostock

Junior research group leader

Dr. Revathi Appali

Fellowship holders

Sushain Magotra (finished)