Summary of the work programme
For therapies employing electrically active implants, numerical models are central in determining the resulting electric field distribution in the targeted tissue. Only multi-scale models that also include interacting bioelectrical, biochemical, biomechanical and thermal effects meet the specific character of biological tissue. We will investigate and advance appropriate finite element-based micro- and macroscopic models for bone, cartilage and deep brain as well as scale-bridging techniques and, furthermore, methods for uncertainty quantification as the dielectric tissue properties exhibit large variations. The simulation models will contribute to derive best-possible and robust inter-individual stimulation parameters, and, in turn, a safer therapy planning.