Project C03 - SFB 1270 ELAINE - University of Rostock

C03 – Deep brain stimulation in dystonia models: Biological implementation, definition of optimal stimulation parameters, and analysis of mechanisms

Summary of the work programme

The mechanisms and therapeutic effects of deep brain stimulation in a validated animal model of dystonia are investigated. The goal is to clarify how long-term stimulation in the pallidum influences synaptic and cellular plasticity within and outside the stimulation region. Electrophysiology, high-density multi-electrode arrays, immunohistochemical analyses, and mathematical modelling are used to systematically investigate cholinergic and dopaminergic modulation, structural changes, and biomarkers. The long-term goal is to develop predictive markers and elucidate the mechanisms for future feedback-controlled deep brain stimulation.