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Project number

C03

Project title

Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms

Project leader

Prof. Dr. med. habil. Rüdiger Köhling, Prof. Dr. med. vet. habil. Angelika Richter

Staff

Monique Zwar
Stefanie Perl

Institutions

Oscar-Langendorff-Institute of Physiology; Rostock,
Institute for Pharmacology, Pharmacy and Toxicology; Leipzig

Summary of the work programme

The aim of this project is to clarify the mechanisms of action of deep brain stimulation in dystonia, to define stimulation targets and stimulation paradigms, and to identify therapeutic success markers. We hypothesise that deep brain stimulation improves pathophysiological processes of dystonia, specifically synaptic / cellular plasticity, inhibitory tone and network oscillations via specific network changes, depending on target structure and stimulation parameters. We will therefore analyse the underlying mechanisms of deep brain stimulation, narrow down effective stimulation parameters, identify early biomarkers of therapeutic outcome, and analyse and model the effects of deep brain stimulation on the extended basal ganglia network.

Talks

R. Köhling:
Resilienz bei der Neurodegeneration,
Research Workshop, University Medical Center, Rostock, Nov. 2017