C03 - Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms

Summary of the work programme

Working with the hypothesis that deep-brain stimulation improves pathophysiological processes of dystonia (i.e. synaptic / cellular plasticity, inhibitory drive and network oscillatory states) by means of specific network alterations, whereby it depends on the stimulation targets and paradigms, we will a) analyse the mechanisms of action of deep-brain stimulation, b) narrow down the effective stimulation parameters, c) identify biomarkers predicting outcome and finally d) analyse and model the effects of deep-brain stimulation on the extended basal ganglia network. We expect this to help clarify the mechanisms of action of deep-brain stimulation and to have clinical translational impact for target and paradigm selection as well as therapeutic success prediction. 

Cooperation projects

A02 / A06 / B03 / C04

Publications

2019

Perl, Stefanie; Richter, Franziska; Gericke, Birthe; Richter, Angelika (2019): Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model. In: European journal of pharmacology 859, S. 172527. DOI: 10.1016/j.ejphar.2019.172527.

Richter, Franziska; Bauer, Anne; Perl, Stefanie; Schulz, Anja; Richter, Angelika (2019): Optogenetic augmentation of the hypercholinergic endophenotype in DYT1 knock-in mice induced erratic hyperactive movements but not dystonia. In: EBioMedicine 41, S. 649–658. DOI: 10.1016/j.ebiom.2019.02.042.

Rohde, Marco; Ziebart, Josefin; Kirschstein, Timo; Sellmann, Tina; Porath, Katrin; Kühl, Friederike et al. (2019): Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels. In: Frontiers in bioengineering and biotechnology 7, S. 422. DOI: 10.3389/fbioe.2019.00422.


2018

Ziebart, Josefin; Sellmann, Tina; Porath, Karin; Delenda, Bachir; van Rienen, Ursula; Bader, Rainer; Köhling, Rüdiger (2018): Investigation of calcium channels involved in directed migration of human osteoblast in a direct current field. In: Orthopaedic Proceedings SUPP\_4, S. 4. DOI: 10.1302/1358-992X.2018.4.004.

Conference papers

2020

Lüttig, Anika; Perl, Stefanie; Richter, Franziska; Morawski, M.; Richter, Angelika (2020): Examinations of brevican in a genetic mouse model of DYT1 dystonia. Abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) with contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH). Leipzig, Germany, March 2020. Verlag Springer Nature Switzerland AG.

Paap, Maria; Perl, Stefanie; Lüttig, Anika; Plocksties, Franz; Niemann, Christoph; Timmermann, Dirk et al. (2020): Deep brain stimulation as a therapeutic option in dystonia: effects of different frequencies in a phenotypic animal model by using an optimized stimulator. Abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) With contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH). 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology. Leipzig, Germany, March 2020. Verlag Springer Nature Switzerland AG.

Talks

2017

Köhling, Rüdiger (2017): Resilienz bei der Neurodegeneration. University Medical Center. Rostock, Germany, November 2017.

Posters

2019

Zwar, Monique; Franz, Denise; Rohde, Marco; Neubert, Valentin; Paap, Maria; Perl, Stefanie et al. (2019): Modulation of cortico-striatal GABAergic inhibition by short-term deep brain stimulation in a phenotypic animal model of dystonia. 98th Meeting of the German Physiological Society. Ulm, Germany.