C03 - Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms

Summary of the work programme

Working with the hypothesis that deep-brain stimulation improves pathophysiological processes of dystonia (i.e. synaptic / cellular plasticity, inhibitory drive and network oscillatory states) by means of specific network alterations, whereby it depends on the stimulation targets and paradigms, we will a) analyse the mechanisms of action of deep-brain stimulation, b) narrow down the effective stimulation parameters, c) identify biomarkers predicting outcome and finally d) analyse and model the effects of deep-brain stimulation on the extended basal ganglia network. We expect this to help clarify the mechanisms of action of deep-brain stimulation and to have clinical translational impact for target and paradigm selection as well as therapeutic success prediction. 

Cooperation projects

A02 / A06 / B03 / C04

Publications

Stefanie Perl, Franziska Richter, Birthe Gericke, Angelika Richter: Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model. Eur J Pharmacol., 7/2019 5;859:172527. September 2019. doi:10.1016/j.ejphar.2019.172527

Josefin Ziebart, Tina Sellmann, Karin Porath, Bachir Delenda, Ursula van Rienen, Rainer Bader and Rüdiger Köhling: Investigation of calcium channels involved in directed migration of human osteoblast in a direct current field. Orthopaedic Proceedings, volume SUPP_4: pages 4-4, April 2018. online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.2018.4.004

Franziska Richter, Anne Bauer, Stefanie Perl, Anja Schulz, Angelika Richter: Optogenetic augmentation of the hypercholinergic endophenotype in DYT1 knock-in mice induced erratic hyperactive movements but not dystonia. EBioMedicine 41, 649-658, March 2019. doi.org/10.1016/j.ebiom.2019.02.042

Talks

Rüdiger Köhling: Resilienz bei der Neurodegeneration, Research Workshop, University Medical Center, November 2017, Rostock, Germany.