C03 – Deep brain stimulation in dystonia models: Biological implementation, definition of optimal stimulation parameters, and analysis of mechanisms
Summary of the work programme
The mechanisms and therapeutic effects of deep brain stimulation in a validated animal model of dystonia are investigated. The goal is to clarify how long-term stimulation in the pallidum influences synaptic and cellular plasticity within and outside the stimulation region. Electrophysiology, high-density multi-electrode arrays, immunohistochemical analyses, and mathematical modelling are used to systematically investigate cholinergic and dopaminergic modulation, structural changes, and biomarkers. The long-term goal is to develop predictive markers and elucidate the mechanisms for future feedback-controlled deep brain stimulation.
Project leader
Prof. Dr. med. habil. Rüdiger Köhling
E-Mail
Tel.: +49 381 494 8000
Prof. Dr. med. vet. Franziska Richter Assêncio
E-Mail
Tel.: +49 511 953 8721
Institutions
Rostock University Medical Centre
Oscar Langendorff Institute of Physiology
Gertrudenstraße 9
18057 Rostock
University of Veterinary Medicine Hannover
Department of Pharmacology, Toxicology and Pharmacy
Bünteweg 17, Gebäude 218
30559 Hannover