B03 - Energy-autonomous platform for electrical stimulation implants

Summary of the work programme

This project provides a highly integrated, ultra-low-power electronic system to be used in novel electrically active implants, as proposed in this CRC. The research is oriented towards a predominantly digital, intelligent platform. We propose a modular Software Defined Implant Platform that allows for software based, patient-specific and closed-loop electrical stimulation, configuration for different types of implants and management of multiple sources of energy. Sub-cutaneous thermoelectric energy harvesting will be explored in order to make it available for the implants in this CRC. The platform enables remote configuration and monitoring of the implant's operational parameters as well as monitoring of the patient's biological status.

Cooperation projects

A02 / B02 / B05 / C01 / C02 / C03 / C04

Publications

2020

Niemann, Christoph; Ali, Munawar; Shah, Obaid Ullah; Heller, Jakob; Timmermann, Dirk (2020): Sensor based adaptive voltage scaling on FPGAs: Calibration and parametrization. In: Integration 75, S. 30–39. DOI: 10.1016/j.vlsi.2020.05.006 .

Yuan, Chengdong; Kreß, Stefanie; Sadashivaiah, Gunasheela; Rudnyi, Evgenii B.; Hohlfeld, Dennis; Bechtold, Tamara (2020): Towards efficient design optimization of a miniaturized thermoelectric generator for electrically active implants via model order reduction and submodeling technique. In: International Journal for Numerical Methods in Biomedical Engineering 36 (4), e3311. DOI: 10.1002/cnm.3311.

Conference papers

2020

Heller, Jakob; Niemann, Christoph; Plocksties, Franz; Haubelt, Christian; Timmermann, Dirk (2020): Towards Virtual Prototyping of Electrically Active Implants Using SystemC-AMS. Workshop Methods and Description Languages for Modelling and Verification of Circuits and Systems (MBMV): VDE-Verlag Stuttgart. Online verfügbar unter https://www.vde-verlag.de/proceedings-de/455220003.html.

Niemann, Christoph; Ewert, Christian; Puttnies, Henning; Rethfeldt, Michael; Timmermann, Dirk; Danielis, Peter (2020): Modeling Energy Consumption for Task-Offloading Decisions on Mobile and Embedded Devices. IEEE Conference on Life Sciences and Technologies (LifeTech). Kyoto, Japan, March 2020.

Paap, Maria; Perl, Stefanie; Lüttig, Anika; Plocksties, Franz; Niemann, Christoph; Timmermann, Dirk et al. (2020): Deep brain stimulation as a therapeutic option in dystonia: effects of different frequencies in a phenotypic animal model by using an optimized stimulator. Abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) With contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH). 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology. Leipzig, Germany, March 2020. Verlag Springer Nature Switzerland AG.

Plocksties, Franz; Niemann, Christoph; Bader, Rainer; Möws, Fabian; Seitz, Hermann; Kämmerer, Peer W. et al. (2020): Requirements and Design of an Implant for Electrical Stimulation for Bone Regeneration in Animals. IEEE Conference on Life Sciences and Technologies (LifeTech). Kyoto, Japan, March 2020.
 

2019

Kreß, Stefanie; Verma, Ujjval; Hohlfeld, Dennis (2019): Bioheat Modeling for the Design of Thermoelectric Energy Harvesting Implants. Mikrosystemtechnik-Kongress des Bundesministeriums für Bildung und Forschung und des Verbandes der Elektrotechnik Elektronik Informationstechnik e. V. Berlin, Deutschland, October 2019.

Lange, Hans-E.; Hohlfeld, Dennis; Kluess, Daniel (2019): Piezoelectric Energy Harvesting Concept for Energy-Autonomous Instrumented Orthopaedic Implants a Numerical Evaluation. 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. New York, United States of America, August 2019.

Niemann, Christoph; Ali, Munawar; Heller, Jakob; Timmermann, Dirk (2019): A Calibration Procedure for Sensor Based Adaptive Voltage Scaling Approaches. 29th International Symposium on Power and Timing Modeling, Optimization and Simulation (PATMOS) DOI: 10.1109/PATMOS.2019.8862075 .

Niemann, Christoph; Plocksties, Franz; Heller, Jakob; Timmermann, Dirk (2019): Towards an energy autonomous platform for electrically active implants. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Berlin, Germany, July 2019.

Yuan, Chengdong; Sadashivaiah, Gunasheela; Kreß, Stefanie; Rudnyi, Evgenii B.; Bechtold, Tamara (2019): A Combination of POD-based Model Order Reduction and Thermal Submodeling for Miniaturized Thermoelectric Generator. Mikrosystemtechnik-Kongress des Bundesministeriums für Bildung und Forschung sowie des Verbandes der Elektrotechnik, Elektronik und Informationstechnik. Berlin, Germany, October 2019.
 

2018

Bernhardt, Jakob; Verma, Ujjwal; Hohlfeld, Dennis (2018): Thermoelektrische Energieversorgung subkutaner Implantate. Workshop Energieautonome Sensorsysteme des Verbandes Deutscher Elektrotechnik, Elektronik und Informationstechnik/Verband Deutscher Ingenieure-Ges. Mikroelektronik Mikrosystem- u. Feinwerktechnik. Dresden, Germany, February 2018.

Jadhav, Onkar Sandip; Rudnyi, Evgenii B.; Bechtold, Tamara (2018): Load Snapshot Based Nonlinear-Input Model Order Reduction of a Thermal Human Tissue Model. The 12th International Conference on Scientific Computing in Electrical Engineering. Taormina, Italy, September 2018.

Jadhav, Onkar Sandip; Yuan, Chengdong; Rudnyi, Evgenii B.; Hohlfeld, Dennis; Bechtold, Tamara (2018): Nonlinear-Input Model Order Reduction of a Thermoelectric Generatorfor Electrically Active Implants. International Conference on Bioelectromagnetism. Aachen, Germany, May 2018.

Verma, Ujjwal; Bernhardt, Jakob; Hohlfeld, Dennis (2018): Modeling and simulation of bioheat powered subcutaneous thermoelectric generator. European Conference on Modelling and Simulation. Wilhelmshaven, Germany, May 2018.

Yuan, Chengdong; Jadhav, Onkar Sandip; Rudnyi, Evgenii B.; Hohlfeld, Dennis; Bechtold, Tamara (2018): Parametric Model Order Reduction of a Thermoelectric Generator for Electrically Active Implants. International Conference on Thermal, Mechanical and Multiphysics Simulation and Experiments in Microelectronics and Microelectronics and Microsystems of the European Center for Micro- and Nanoreliability. Toulouse, France, April 2018.
 

2017

Bernhardt, Jakob; Verma, Ujjwal; Bechtold, Tamara, Hohlfeld, Dennis (2017): Entwurf eines thermoelektrischen Generators für elektrisch aktive Implantate. ANalysis SYStem Conference. Koblenz, Germany, November 2017.

Jadhav, Onkar Sandip; Yuan, Chengdong; Hohlfeld, Dennis; Bechtold, Tamara (2017): Entwurf eines thermoelektrischen Generators für elektrisch aktive Implantate. Mikrosystemtechnik-Kongress. Munich, Germany, October 2017.

Talks

2020

Rao, Yongchen; Kreß, Stefanie; Yuan, Chengdong; Bechtold, Tamara; Hohlfeld, Dennis (2020): Thermoelectric energy harvesting in medical implants. Workshop der VDE/VDI-Gesellschaft Mikroelelektronik, Mikrosystem- und Feinwerktechnik, Bereich Energieautonome Sensorsysteme. VDE/VDI-GMM. Karlsruhe, Germany, March 2020.

Yuan, Chengdong; Hohlfeld, Dennis; Bechtold, Tamara (2020): Optimum Thermal Matching of a Miniaturized Thermoelectric Generator via Parametric Model Order Reduction. 21st International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Microelectronics and Microsystems EuroSimE. virtuell, July 2020.
 

2019

Niemann, Christoph; Heller, Jakob; Plocksties, Franz; Enkhtuvshin, Janchivnyambuu; Timmermann, Dirk (2019): Reliability Enhancement of Signal Processing Hardware Accelerators for Closed Loop Deep Brain Stimulation. Arbeitskreis „Zuverlässigkeit von Implantaten und Biostrukturen“ des Deutschen Verbandes für Materialforschung und –prüfung. Rostock, Germany, November 2019.


2017

Hohlfeld, Dennis (2017): Energieautonome Implantate mit rückgekoppelter elektrischer Stimulation. Fachverband für Mikrotechnik e.V. - Fachgruppe Medizintechnik. Altenberge, Germany, November 2017.

Timmermann, Dirk (2017): Collaborative Research Centre 1270 ELAINE - ELectrically Active ImplaNts. Symposium and Panel Medizintechnik. Darmstadt, Germany, November 2017.

Posters

2019

Lange, Hans-E.; Hohlfeld, Dennis; Kluess, Daniel (2019): Piezoelectric energy harvesting concept for an energy autonomous instrumented orthopaedic implant - a numerical evaluation. 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 4th Conference on Imaging and Visualization. New York, United States of America.