B01 - Electrically conductive and piezoactive materials for multifunctional implants for bone and cartilage regeneration

Summary of the work programme

In this project electrically conductive and piezoactive materials will be established that can be processed by additive manufacturing technologies in order to fabricate multifunctional implants for enhanced bone and cartilage regeneration. Electrically conductive polymers as well as blends of hydrogels and electrically conductive polymers will be used as feedstock for scaffolds for cartilage regeneration. Piezoceramics functionalised with bioactive glasses will be investigated, with the proliferation of osteoblasts being induced via the piezoeffect. Furthermore, highly structured titanium surfaces will be coated with electrically conducting polymers incorporated with bioglass in order to change their properties from bioinert to bioactive.

Cooperation projects

A01 / A02 / B03 / B05 / C01 / C02

Publications

2020

Distler, Thomas; Fournier, Niklas; Grünewald, Alina; Polley, Christian; Seitz, Hermann; Detsch, Rainer; Boccaccini, Aldo R. (2020): Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization. In: Front. Bioeng. Biotechnol. 8. DOI: 10.3389/fbioe.2020.00552 .

Distler, Thomas; McDonald, Kilian; Heid, Susanne; Karakaya, Emine; Detsch, Rainer; Boccaccini, Aldo R. (2020): Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering. In: ACS Biomater. Sci. Eng.DOI: 10.1021/acsbiomaterials.0c00677 .

Polley, Christian; Distler, Thomas; Detsch, Rainer; Lund, Henrik; Springer, Armin; Boccaccini, Aldo R.; Seitz, Hermann (2020): 3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering. In: Materials (Basel, Switzerland) 13 (7). DOI: 10.3390/ma13071773.

Schnell, Georg; Polley, Christian; Bartling, Stephan; Seitz, Hermann (2020): Effect of Chemical Solvents on the Wetting Behavior Over Time of Femtosecond Laser Structured Ti6Al4V Surfaces. In: Nanomaterials (Basel, Switzerland) 10 (6). DOI: 10.3390/nano10061241 .
 

2019

Distler, Thomas; Boccaccini, Aldo R. (2019): 3D printing of electrically conductive hydrogels for tissue engineering and biosensors - A review. In: Acta biomaterialia. DOI: 10.1016/j.actbio.2019.08.044.

Maizza, Giovanni; Caporale, Antonio; Polley, Christian; Seitz, Hermann (2019): Micro-Macro Relationship between Microstructure, Porosity, Mechanical Properties, and Build Mode Parameters of a Selective-Electron-Beam-Melted Ti-6Al-4V Alloy. In: Metals 9 (7), S. 786. DOI: 10.3390/met9070786 .

Schnell, Georg; Stählke, Susanne; Duenow, Ulrike; Nebe, Barbara J.; Seitz, Hermann (2019): Femtosecond Laser Nano/Micro Textured Ti6Al4V Surfaces-Effect on Wetting and MG-63 Cell Adhesion. In: Materials 12 (13). DOI: 10.3390/ma12132210.

Conference papers

2019

Distler, Thomas; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): 3D Printing and the characterization of an electrically conductive, alginate di-aldehyde-gelatin and polystyrene sulfonate doped polypyrrole (ADA-GEL-PPy:PSS) composite hydrogel for tissue engineering applications. 4th Euro Intelligent Materials 2019. Kiel, Germany, June 2019.

Distler, Thomas; Polley, Christian; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): Development of 3D printed Electrically Conductive Oxidized Alginate and Gelatin based Polypyrrole-Polystyrenesulfonate (PPy:PSS) Hydrogels for Functional Tissue Engineering Applications. 30th Annual Conference of the European Society for Biomaterials (ESB). Dresden, Germany, September.

Distler, Thomas; Polley, Christian; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): Engineering of a 3D Printable, Conductive, Alginate-based Biopolymer-Polypyrrole Composite for Electrically Active Implants. Jahrestagung der Deutschen Gesellschaft für Biomaterialien. Braunschweig, Germany, November 2019.

Polley, Christian; Distler, Thomas; Rüffer, David; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): 3D printing of piezoelectric composite ceramics for bone tissue engineering. Proceedings of international workshop on piezoelectric materials for biomedical applications. International workshop on piezoelectric materials for biomedical applications. Trondheim, Norway, March 2019.

Polley, Christian; Distler, Thomas; Rüffer, David; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): 3D printing of smart materials for bone regeneration. Transactions on Additive Manufacturing Meets Medicine Vol 1. Lübeck, Germany, September 2019.

Polley, Christian; Distler, Thomas; Rüffer, David; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): 3D printing of piezoelectric barium titanate/ hydroxyapatite composite ceramics for bone tissue engineering. 4th Euro Intelligent Materials 2019. Kiel, Germany, June 2019.

Polley, Christian; Distler, Thomas; Weizel, Alina; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): Bioactive and electrically conductive polymer-coated titanium structures for load-bearing implants. Rostock, November 27-28, 2019. Workshop Deutscher Verbande für Materialforschung und –prüfung, Arbeitskreis „Zuverlässigkeit von Implantaten und Biostrukturen“. Rostock, Germany, November 2019.

Sahm, Franziska; Grote, Vivica Freein; Detsch, Rainer; Krelel, Thomas; Boccaccini, Aldo R.; Bader, Rainer; Jonitz‑Heincke, Anika (2019): Influence of low-frequency alternating electrical fields on the bone remodeling capacity of human osteoblast. European Orthopaedic Research Society. Maastricht, Netherlands, October 2019.

Weizel, Alina; Distler, Thomas; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): Relaxation Behaviour of Ionically and Enzymatically Microbial Transglutaminase (mTG)-Crosslinked Alginate-di-aldehyde and Gelatin (ADA-GEL) Hydrogels for Cartilage Regeneration. 4th Euro Intelligent Materials 2019. Kiel, Germany, June 2019.
 

2018

Boccaccini, Aldo R. (2018): Bioactive materials and biofabrication approaches for hard tissue regeneration. 2nd Sino-German Symposium on Reconstruction and Repair of Musculoskeletal Tissues. Mainz, Germany, March 2018.

Talks

2018

Polley, Christian; Distler, Thomas; Rüffer, David; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2018): Initial study on 3D printing of piezoelectric barium titanate ceramics for bone tissue engineering. MSE-Congress. Darmstadt, Germany September 2018. Materials Science and Engineering (MSE)-Congress. Darmstadt, Germany, September 2018.

Posters

2019

Distler, Thomas; Polley, Christian; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): Development of 3D printed Electrically Conductive Oxidized Alginate and Gelatin based Polypyrrole-Polystyrenesulfonate (PPy:PSS). Hydrogels for Functional Tissue Engineering Applications. Dresden, Germany.

Distler, Thomas; Polley, Christian; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): Engineering of a 3D Printable, Conductive, Alginate-based Biopolymer-Polypyrrole Composite for Electrically Active Implants. Jahrestagung der Deutschen Gesellschaft für Biomaterialien. Jahrestagung der Deutschen Gesellschaft für Biomaterialien. Braunschweig, Germany.

Distler, Thomas; Schwarz, Silke; Kuth, Sonja; Gögele, Clemens; Stölzel, Katharina; Detsch, Rainer et al. (2019): 3D printing and characterization of human nasal chondrocyte (hNSC) laden dual cross-linked oxidized alginate-gelatin (ADA-GEL) hydrogels for cartilage repair approaches. Enterprise Service Bus. Dresden, Germany.

Weizel, Alina; Distler, Thomas; Polley, Christian; Detsch, Rainer; Boccaccini, Aldo R. (2019): Mechanical and rheological characterization of hydrogels and hydrogel precursors for cartilage tissue engineering and biofabrication. Additive Manufacturing Meets Medicine + 3D Week. Lübeck, Germany.

Weizel, Alina; Distler, Thomas; Polley, Christian; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): Relaxation Behavior of Ionically and Enzymatically Microbial Transglutaminase (mTG)-Crosslinked Alginate-di-aldehyde and Gelatin (ADA-GEL) Hydrogels for Cartilage Regeneration. 4th Euro Intelligent Materials. Kiel, Germany.