B01 - Electrically conductive and piezoactive materials for multifunctional implants for bone and cartilage regeneration
Summary of the work programme
In this project electrically conductive and piezoactive materials will be established that can be processed by additive manufacturing technologies in order to fabricate multifunctional implants for enhanced bone and cartilage regeneration. Electrically conductive polymers as well as blends of hydrogels and electrically conductive polymers will be used as feedstock for scaffolds for cartilage regeneration. Piezoceramics functionalised with bioactive glasses will be investigated, with the proliferation of osteoblasts being induced via the piezoeffect. Furthermore, highly structured titanium surfaces will be coated with electrically conducting polymers incorporated with bioglass in order to change their properties from bioinert to bioactive.
Polley, Christian; Distler, Thomas; Detsch, Rainer; Lund, Henrik; Springer, Armin; Boccaccini, Aldo R.; Seitz, Hermann (2020): 3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering. In: Materials (Basel, Switzerland) 13 (7). DOI: 10.3390/ma13071773.
Distler, Thomas; Boccaccini, Aldo R. (2019): 3D printing of electrically conductive hydrogels for tissue engineering and biosensors - A review. In: Acta biomaterialia. DOI: 10.1016/j.actbio.2019.08.044.
Schnell, Georg; Stählke, Susanne; Duenow, Ulrike; Nebe, Barbara J.; Seitz, Hermann (2019): Femtosecond Laser Nano/Micro Textured Ti6Al4V Surfaces-Effect on Wetting and MG-63 Cell Adhesion. In: Materials 12 (13). DOI: 10.3390/ma12132210.
Sahm, Franziska; Grote, Vivica Freein; Detsch, Rainer; Krelel, Thomas; Boccaccini, Aldo R.; Bader, Rainer; Jonitz‑Heincke, Anika (2019): Influence of low-frequency alternating electrical fields on the bone remodeling capacity of human osteoblast. European Orthopaedic Research Society. Maastricht, Netherlands, October 2019.
Boccaccini, Aldo R. (2018): Bioactive materials and biofabrication approaches for hard tissue regeneration. 2nd Sino-German Symposium on Reconstruction and Repair of Musculoskeletal Tissues. Mainz, Germany, March 2018.
Distler, Thomas; Polley, Christian; Detsch, Rainer; Seitz, Hermann; Boccaccini, Aldo R. (2019): Development of 3D printed Electrically Conductive Oxidized Alginate and Gelatin based Polypyrrole-Polystyrenesulfonate (PPy:PSS). Hydrogels for Functional Tissue Engineering Applications. Dresden, Germany.
Distler, Thomas; Schwarz, Silke; Kuth, Sonja; Gögele, Clemens; Stölzel, Katharina; Detsch, Rainer et al. (2019): 3D printing and characterization of human nasal chondrocyte (hNSC) laden dual cross-linked oxidized alginate-gelatin (ADA-GEL) hydrogels for cartilage repair approaches. Enterprise Service Bus. Dresden, Germany.
Weizel, Alina; Distler, Thomas; Polley, Christian; Detsch, Rainer; Boccaccini, Aldo R. (2019): Mechanical and rheological characterization of hydrogels and hydrogel precursors for cartilage tissue engineering and biofabrication. Additive Manufacturing Meets Medicine + 3D Week. Lübeck, Germany.
Weizel, Alina; Distler, Thomas; Polley, Christian; Detsch, Rainer; Boccaccini, Aldo R.; Seitz, Hermann (2019): Relaxation Behavior of Ionically and Enzymatically Microbial Transglutaminase (mTG)-Crosslinked Alginate-di-aldehyde and Gelatin (ADA-GEL) Hydrogels for Cartilage Regeneration. 4th Euro Intelligent Materials. Kiel, Germany.
Friedrich-Alexander University of Erlangen-Nuremberg
Chair of Biomaterials