A07 – Image-based modelling of angiogenesis and tissue remodelling for electrically active implants
Summary of the work programme
The goal is to develop a multiscale angiogenesis model and investigate the influence of electrical stimulation on the healing of bone and osteochondral defects. This model will serve as a basis for simulating bone remodelling, as angiogenesis is crucial in bone healing. Likewise, the vascularisation of subchondral bone, essential for nutrient supply, is explicitly modelled. Furthermore, a multiscale model of the chondrocyte response to electrical stimulation is established. The coupling of the models should provide insight into the extent to which stimulation parameters or the design of implant scaffolds can be specifically adapted.
Project leader
Prof. Dr. Berit Zeller-Plumhoff
E-Mail
Tel.: +49 381 498 9620
Institution
University of Rostock
Chair for Data-Driven Analysis and Design of Materials
Albert-Einstein-Straße 2
18059 Rostock
Staff
N.N.
E-Mail
Associated staff
Dr.-Ing. Carsten Wickmann